Cephem derivatives and processes for their manufacture

Details Cephem derivatives and processes for their manufacture Cephem derivatives and processes for their manufacture

C - Chemistry, Metallurgy

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C07D 501/20 (2006.01) A61K 31/545 (2006.01) A61K 31/675 (2006.01) A61K 31/695 (2006.01) C07D 501/00 (2006.01) C07D 501/24 (2006.01) C07D 501/34 (2006.01) C07D 501/36 (2006.01) C07D 501/46 (2006.01) C07D 501/59 (2006.01) C07D 501/60 (2006.01)

Patent

CA 1161836

HOE 77/F 079 CEPHEM DERIVATIVES AND PROCESSES FOR THEIR MANUFACTURE Abstract of the disclosure: Cephem derivatives of the formula Image in which R1 denotes hydrogen, an optionally substituted al- kyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino- protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkerlyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkyl- sulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of nucleophilic compound, and in which the R2O group is in the syn-position are valuable chemotherapeutic agents which possess a very powerful antimicrobial action against Gram-postive and Gram- negative bacteria, have an unexpectedly god action against penicillinase- forming Staphilococci.

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