Ceramide-analogous metabolites

Details Ceramide-analogous metabolites Ceramide-analogous metabolites

A - Human Necessities

61

K

A61K 31/165 (2006.01) A61P 25/28 (2006.01) A61P 37/06 (2006.01) C07C 233/18 (2006.01)

Patent

CA 2752003

This invention relates to certain ceramide-analogues of FTY720 (2-amino-2-[2- (4-octylphenyl)ethyl]propane-1,3-diol; fingolimod). In particular, the present invention relates to pharmaceutical compositions comprising these compounds, as well as processes for their preparation and their use in the treatment of autoimmune conditions, such as multiple sclerosis.

Cette invention concerne certains analogues de type céramides de FTY720 (2-amino-2-[2-(4-octylphényl)éthyl]propane-1,3-diol; fingolimod). En particulier, la présente invention concerne des compositions pharmaceutiques contenant ces composés ainsi que des procédés pour leur préparation et leur utilisation dans le traitement d'affections auto-immunes, telles que la sclérose en plaques.

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