Ceramide compound, process for preparing it and its use

Details Ceramide compound, process for preparing it and its use Ceramide compound, process for preparing it and its use

C - Chemistry, Metallurgy

07

C

C07C 275/10 (2006.01) A01N 47/28 (2006.01) A01N 55/10 (2006.01) A61K 8/68 (2006.01) C07C 275/16 (2006.01) C07C 275/20 (2006.01) C07F 7/08 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2250479

The invention relates to novel ceramide compounds, the process for preparing them and their use, particularly in the treatment and care of skin, hair, nails and eyelashes, in cosmetic or pharmaceutical applications; the compounds are of the formula (I): R1 - CH(OH) - CH(CH2OH) - NH - CO - NR2R3, wherein: * R1 is a saturated or unsaturated, linear or branched, optionally hydroxylated C9 to C23 alkyl radical, * R2 is hydrogen or a saturated or unsaturated, linear or branched, C1 to C8 alkyl radical, * R3 is a linear or branched, saturated or unsaturated, optionally hydroxylated, C1 to C32 alkyl radical; the said hydroxyl radical can be substituted with a linear or branched, saturated or unsaturated, C1 to C24 acyl radical; the said group R3 can optionally be broken by 1 to 7 heteroatoms. The advantage of synthetic ceramides over ceramides of animal origin is that they are free of all risk of contamination by the agent responsible for BSE.

L'invention concerne de nouveaux composés de type céramide, leur procédé de préparation ainsi que leur utilisation, notamment pour le traitement et le soin de la peau, des cheveux, des ongles et des cils, en cosmétique ou en pharmaceutique; les composés répondent à la formule (I): R1 - CH(OH) - CH(CH2OH) - NH - CO - NR2R3 Dans laquelle: * R1 désigne un radical alkyle, saturé ou insaturé, linéaire ou ramifié, éventuellement hydroxylé, en C9 à C23, * R2 désigne l'hydrogène ou un radical alkyle, saturé ou insaturé, linéaire ou ramifié, en C1 à C8, * R3 désigne un radical alkyle, linéaire ou ramifié, saturé ou insaturé, éventuellement hydroxylé, en C1 à C32, ledit radical hydroxyle pouvant lui-même être substitué par un radical acyle, linéaire ou ramifié, saturé ou insaturé, en C1 à C24; ledit groupement R3 peut éventuellement être interrompu par 1 à 7 hétéroatomes. Ces céramides synthétiques présentent l'avantage par rapport aux céramides d'origine animale d'être dépourvus de tout risque de contamination par l'agent responsable de la BSE.

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