Ceramide kinase modulation

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 277/82 (2006.01) A61K 31/428 (2006.01) A61P 3/10 (2006.01) A61P 15/08 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2644636

A compound of formula (I) wherein R1 is a straight chain, branched or cyclic aliphatic, aromatic or heterocyclyl group comprising at least 8 carbon atoms, e.g. 8 to 22, R2 is a straight chain, branched or cyclic aliphatic, aromatic or heterocyclic group comprising from 1 to 12 carbon atoms, and ring A is heterocycyl, fused with the phenyl ring to which ring A is attached comprising 5 or 6 ring members, and 1 to 4 heteroatoms selected from N,S,O; wherein certain compounds are excluded by proviso and the use of such compounds without proviso as pharmaceuticals in disorders which are mediated by ceramide kinase.

L'invention a pour objet un composé de formule (I) où R1 reprèsente un groupe à chaîne droite, ramifié ou aliphatique cyclique, aromatique ou hétérocyclyle comprenant au moins 8 atomes de carbone, p. ex. entre 8 et 22; R2 représente un groupe à chaîne droite, ramifié ou aliphatique cyclique, aromatique ou hétérocyclique comprenant entre 1 et 12 atomes de carbone, et l'anneau A est hétérocyclyle, fusionné avec l'anneau phényle auquel l'anneau A est fixé et comprend 5 ou 6 éléments cycliques et entre 1 et 4 hétéroatomes sélectionnés dans N, S, O; certains composés selon l'invention étant exclus par réserve, et lesdits composés étant utilisés sans réserve en tant que produits pharmaceutiques dans des troubles induits par la céramide kinase.

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