C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 205/00 (2006.01) C07D 207/00 (2006.01) C07D 211/00 (2006.01) C07D 221/00 (2006.01) C07D 233/00 (2006.01) C07D 241/04 (2006.01)
Patent
CA 2585645
The invention provides the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of formula (I) and their use in treating or preventing diseases associated with cell overproliferation and dysfunctional sphingolipid signal transduction. The invention also encompasses the use of the compounds in combination with an apoptosis-signaling ligand, such as Fas ligand. Preferably, the Fas ligand is administered in the form of a gene therapy agent.
L'invention porte sur des composés de formule (I) et sur leurs sels pharmacocompatibles. Les R1, R2, R3, R4, A, X, Y, a, b et n de ladite formule sont tels que définis dans la description. L'invention porte également sur des procédés d'élaboration desdits composés de formule (I), sur leur utilisation pour traiter ou prévenir des maladies associées à la surprolifération de cellules et à un dysfonctionnement de la transduction du signal du sphingolipide, et sur l'utilisation desdits composés en association avec un ligand de signalisation de l'apoptose tel que le ligand Fas lequel est de préférence administré sous la forme d'un agent de thérapie génique.
Bielawska Alicja
Bielawski Jacek
Dong Jian-Yun
El-Zawahry Ahmed
Hannun Yusuf A.
Musc Foundation For Research Development
Norton Rose Or S.e.n.c.r.l.,s.r.l./llp
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