Cerebral hyperkinemic composition containing a...

Details Cerebral hyperkinemic composition containing a... Cerebral hyperkinemic composition containing a...

A - Human Necessities

61

K

167/223

A61K 31/495 (2006.01)

Patent

CA 1328076

ABSTRACT A cerebral hyperkinemic composition which containa as an effective ingredient at least a dihydropyridine derivative of the general formula Image wherein R1, R2 and R3, which are identical or different, independently represent an alkyl, a cycloalkyl or an alkoxy- alkyl; R4 and R5, which are identical or different, independ- ently represent a hydrogen atom, a halogen, nitro, a haloge- nated alkyl, an alkylsulfonyl, a halogenated alkoxy, an alkyl- sulfinyl, an alkyl, a cycloalkyl, an alkoxy, cyano, an alkoxy- carbonyl or an alkylthio, both R4 and R5 not being a hydrogen atom; X represents vinylene or azomethine group; A represents an alkylene; and Ar represents a phenyl, which may be substi- tuted, or an acid addition salt thereof in an effective amount. The dihydropyridine derivatives (I) and their acid addition salts have extremely low toxicity and potent and lasting cerebral vasodilative actions in mammals, and thus are useful as cerebral vasodilators and agents for the prophylaxis and therapy of cerebral circulation disorders.

599828

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