C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07C 233/13 (2006.01) C07C 315/00 (2006.01) C07C 317/28 (2006.01) C07C 319/14 (2006.01) C07C 323/41 (2006.01) C07D 239/38 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2209938
This invention relates to certain 5-(optionally substituted aryl or heteroaryl)-4-(optionally substituted heteroaryl)-1-(optionally substituted heterocyclyl or heterocyclylalkyl) or 1- optionally substituted alkyl or alkenyl -imidazoles and derivatives thereof. Synthetic processes for the preparation of said tri-substituted imidazoles is described. The aforementioned imidazoles are useful for treating cytokine mediated diseases. The compounds of the invention are incorporated into pharmaceutical compositions for use in treating cytokine related diseases.
L'invention concerne certains imidazoles 5-(aryle ou hétéroaryle éventuellement substitué)-4-(hétéroaryle éventuellement substitué)-1-(hétérocyclyle ou hétérocyclylalkyle éventuellement substitué) ou 1-alcényle ou alkyle éventuellement substitué et des dérivés de ces imidazoles. L'invention concerne également des procédés de synthèse pour la préparation de ces imidazoles trisubstitués. Ces imidazoles sont utiles pour traiter les maladies induites par la cytokine. Les composés de l'invention sont incorporés dans des compositions pharmaceutiques permettant de traiter les maladies liées à la cytokine.
Adams Jerry Leroy
Boehm Jeffrey Charles
Gallagher Timothy F.
Garigipati Ravi Shanker
Lee John Cheung-Lun
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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