Certain 3-substituted 2-alkyl benzofuran derivatives

Details Certain 3-substituted 2-alkyl benzofuran derivatives Certain 3-substituted 2-alkyl benzofuran derivatives

C - Chemistry, Metallurgy

07

D

260/279.3, 260/3

C07D 307/81 (2006.01) C07D 307/80 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 1327794

CERTAIN 3-SUBSTITUTED 2-ALKYL BENZOFURAN DERIVATIVES ABSTRACT OF THE DISCLOSURE The disclosure relates to compounds of Formula I Image I and pharmaceutically acceptable addition salts thereof wherein X represents a single, direct bond or a substituted or unsubstituted alkylene chain containing 1 to 4 carbon atoms, wherein R5 is a lower alkyl group, wherein R6 is either hydrogen or methyl, wherein Am is selected from the class consisting of amino, lower mono and dialkylamino, piperidino, piperazino, N-lower alkyl piperazino, pyrrolidino, and morpholino groups, wherein Y1 and Y2 are identical and are hydrogen, a halogen, methyl or ethyl and n is an integer in the range of 1-5. The compounds of the Formula I above and the salts thereof are useful in treating arrhythmic conditions and conditions for which treatment with a vasodilator is indicated. The novel pharmaceutically active agents provided by the present invention can be administered in pharmaceutical dosage forms, internally, for example, parenterally or enterally with dosage adjusted to fit the exigencies of the therapeutic situation.

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