Certain aminomethyl phenylimidazole derivatives; a new class...

Details Certain aminomethyl phenylimidazole derivatives; a new class... Certain aminomethyl phenylimidazole derivatives; a new class...

C - Chemistry, Metallurgy

07

D

C07D 233/64 (2006.01) C07D 233/54 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2098301

This invention encompasses compounds of formulas (I), (II), and (III) where R1 , R3, R4, R6, X, Y, and Z and T are variables; and M is .alpha. or .beta., where R2 is a variable; or R1 and R2 together may represent -(CH2)n1 where n1 is 1, 2, or 3. These compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism. Furthermore compounds of this invention may be useful in treating the extraparamidyl side effects associated with the use of conventional neuroleptic agents.

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