Certain aralkylaminoalkyl esters of 1,4 dihydropyridines as...

Details Certain aralkylaminoalkyl esters of 1,4 dihydropyridines as... Certain aralkylaminoalkyl esters of 1,4 dihydropyridines as...

C - Chemistry, Metallurgy

07

D

167/228, 260/294

C07D 211/90 (2006.01) A61K 31/44 (2006.01) C07C 45/29 (2006.01) C07C 47/55 (2006.01)

Patent

CA 1271196

1,4-DIHYDROPYRIDINE DERIVATIVE, PROCESS FOR PRODUCTION THEREOF, AND PHARMACEUTICAL USE THEREOF ABSTRACT OF THE DISCLOSURE A 1,4-dihydropyridine derivative of the formula Image wherein R1 and R2 are identical or differ- ent and each represents a hydrogen atom, a halogen atom or a nitro group, provided that R1 and R2 are not hydrogen atoms at the same time; R3 represents an alkyl group; R4 represents an aralkyl group which may be substituted; R5 and R7 are identical or different and each represents an alkyl group; R6 represents a hydrogen atom or an alkyl group; R9 represents an alkyl group; R9 represents a hydrogen atom or an alkyl group; n and m are identical or different and each represents an integer of O to 6; provided that when either one of R1 and R2 is a hydrogen atom, R9 is an alkyl group; or an acid addition salt thereof. The 1,4-dihydropyridine derivative is charac- terized by a strong antihypertensive activity and the long duration of the activity.

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