Certain (arylsulfonamido- and pyridyl- or imidazolyl-)...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 213/65 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) C07D 213/55 (2006.01) C07D 213/59 (2006.01) C07D 213/89 (2006.01) C07D 233/54 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 409/00 (2006.01)

Patent

CA 2058384

Certain (Arylsulfonamido- and Pyridyl- or imidazolyl-)-substituted Carboxylic Acids and Derivatives thereof Abstract of the Disclosure The present invention is concerned with compounds of formula I (I) Image wherein A, B, M, R, Ar and Het are as defined in the specification, pharmaceutically acceptable ester and amide derivatives thereof; N-oxides thereof, tetrazole derivatives thereof, and salts thereof. These compounds have valuable pharmacological activities, especially as inhibitors of thromboxane synthetase and as receptor antagonists of thromboxane A2 and prostaglandin H2.

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