Certain benzopyran and benzothiopyran derivatives

Details Certain benzopyran and benzothiopyran derivatives Certain benzopyran and benzothiopyran derivatives

C - Chemistry, Metallurgy

07

D

167/242, 167/244

C07D 311/58 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) C07D 335/06 (2006.01)

Patent

CA 2023016

4-17694/+/CGC 1440 CERTAIN BENZOPYRAN AND BENZOTHIOPYRAN DERIVATIVES Abstract of the Invention The invention relates to the compounds of the formula Image (I) wherein each R independently represents hydrogen, lower alkyl, halogen, trifluoromethyl, lower alkoxy, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryloxy, carbocyclic or heterocyclic aryl-lower alkyloxy, carbocyclic or heterocyclic aryl-lower alkyl, C3-C7-cycloalkyl-lower alkyloxy, or C3-C7-cycloalkyloxy; R1 represents hydrogen, lower alkyl or carbocyclic aryl; R2 represents hydrogen or lower alkyl; Y represents oxygen (O), sulfur (S), sulfinyl or sulfonyl; n represents 1, 2 or 3; A represents a direct bond or lower alkylene; Z represents Image (a) wherein R3 represents hydrogen or acyl; R4 represents lower alkyl, C3-C7-cycloalkyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, or C3-C7-cycloalkyl-lower alkyl; or Z represents Image (b) wherein X represents oxygen or sulfur, R3 represents hydrogen or acyl; R5 represents lower alkyl, lower alkoxycarbonyl-lower alkyl, C3-C7-cycloalkyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, C3-C7-cycloalkyl-lower alkyl, amino, mono- or di-lower alkylamino, lower alkenylamino, lower alkynylamino, carbocyclic or heterocyclic aryl-lower alkylamino, carbocyclic or heterocyclic arylamino, C3-C7-cycloalkylamino, C3-C7-cycloalkyl-lower alkylamino, lower alkoxycarbonyl-lower alkylamino, or lower alkoxy; R6 and R7 independently represent hydrogen or lower alkyl; and pharmaceutically acceptable salts thereof; which are useful as 5-lipoxygenase inhibitors.

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