C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/04 (2006.01) A61K 31/54 (2006.01) C07C 303/40 (2006.01) C07D 279/02 (2006.01) C07D 417/10 (2006.01)
Patent
CA 2296358
The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for Formula (1). The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.
La présente invention concerne un ensemble de dioxydes de benzothiazine ou un de ses sels pharmaceutiquement acceptable, constituant de puissants antagonistes de l'endothéline A avec une forte activité in vitro, ainsi qu'une synthèse améliorée de la formule (1). Les composés sont utiles dans le traitement de taux d'endothéline élevés, de l'hypertension artérielle réno-vasculaire essentielle maligne et de l'hypertension pulmonaire, de l'infarctus cérébral, de l'ischémie cérébrale, de l'insuffisance cardiaque congestive et de l'hémorragie sous-arachnoïdienne.
Bunker Amy Mae
Cheng Xue-Min
Doherty Annette Marian
Edmunds Jeremy John
Kanter Gerald David
Macrae & Co.
Warner-Lambert Company
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