Certain benzothiazine dioxide endothelin antagonists and...

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D 417/04 (2006.01) A61K 31/54 (2006.01) C07C 303/40 (2006.01) C07D 279/02 (2006.01) C07D 417/10 (2006.01)

Patent

CA 2296358

The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for Formula (1). The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.

La présente invention concerne un ensemble de dioxydes de benzothiazine ou un de ses sels pharmaceutiquement acceptable, constituant de puissants antagonistes de l'endothéline A avec une forte activité in vitro, ainsi qu'une synthèse améliorée de la formule (1). Les composés sont utiles dans le traitement de taux d'endothéline élevés, de l'hypertension artérielle réno-vasculaire essentielle maligne et de l'hypertension pulmonaire, de l'infarctus cérébral, de l'ischémie cérébrale, de l'insuffisance cardiaque congestive et de l'hémorragie sous-arachnoïdienne.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Certain benzothiazine dioxide endothelin antagonists and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Certain benzothiazine dioxide endothelin antagonists and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Certain benzothiazine dioxide endothelin antagonists and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1677256

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.