Certain heteroaryl substituted hydroxylamine derivatives

Details Certain heteroaryl substituted hydroxylamine derivatives Certain heteroaryl substituted hydroxylamine derivatives

C - Chemistry, Metallurgy

07

D

C07D 217/24 (2006.01) A61K 31/40 (2006.01) A61K 31/47 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 209/46 (2006.01) C07D 223/16 (2006.01) C07D 279/02 (2006.01) C07D 401/02 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/02 (2006.01) C07D 409/02 (2006.01) C07D 409/06 (2006.01) C07D 417/02 (2006.01)

Patent

CA 2074797

4-18742/A/CGC 1566 CERTAIN HETEROARYL SUBSTITUTED HYDROXYLAMINE DERIVATIVES Abstract of the Disclosure Disclosed are the compound of the formula Image (I) wherein R represents hydrogen, lower alkyl, aryl, biaryl, C3-C7-cycloalkyl, aryl-lower alkyl, aryl-lower alkenyl, aryl-lower alkynyl, aryloxy-lower alkyl, arylthio-lower alkyl, C3-C7-cycloalkyl-lower alkyl, biaryl-lower alkyl, aryl-C3-C7-cycloalkyl, aryl-C3-C7-cycloalkyl-lower alkyl or aryloxy-aryl-lower alkyl; and aryl represents carbocyclic or heterocyclic aryl; Z represents C1-C3-alkylene or vinylene, each unsubstituted or substituted by lower alkyl; Y represents SO2 (sulfonyl) or CO (carbonyl); A represents O (oxygen),S(sulfur),or a direct bond; B represents lower alkylene; or B represents lower alkenylene provided that A represents a direct bond; X represents oxygen or sulfur; R1 represents hydrogen, acyl, lower alkoxycarbonyl, aminocarbonyl, mono- or di-lower alkylaminocarbonyl, lower alkenylaminocarbonyl, lower alkynylaminocarbonyl, carbocyclic or heterocyclic aryl-lower alkylaminocarbonyl,carbocyclic or heterocyclic arylaminocarbonyl, C3-C7-cycloalkylaminocarbonyl or C3-C7-cycloalkyl-lower alkylaminocarbonyl; R2 represents lower alkyl, lower alkoxycarbonyl-lower alkyl, C3-C7-cycloalkyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, C3-C7-cycloalkyl-lower alkyl, amino, mono- or di-lower alkylamino, lower alkenylamino, lower alkynylamino, carbocyclic or heterocyclic aryl-lower alkylamino, carbocyclic or heterocyclic arylamino, C3-C7-cycloalkylamino, C3-C7-cycloalkyl-lower alkylamino or lower alkoxycarbonyl-lower alkylamino; R3 and R4 independently represent hydrogen or lower alkyl; Ra represents hydrogen, lower alkyl, halo, trifluoromethyl or lower alkoxy; and pharmaceutically acceptable salts thereof; which are useful as lipoxygenase inhibitors.

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