Certain pyrrolylphenyl-substituted hydroxamic acid derivatives

Details Certain pyrrolylphenyl-substituted hydroxamic acid derivatives Certain pyrrolylphenyl-substituted hydroxamic acid derivatives

C - Chemistry, Metallurgy

07

D

167/233, 260/326

C07D 207/327 (2006.01) A61K 31/40 (2006.01) C07D 207/325 (2006.01)

Patent

CA 2007085

CERTAIN PYRROLYLPHENYL-SUBSTITUTED HYDROXAMIC ACID DERIVATIVES Abstract of the Disclosure Disclosed are the pyrrolylphenyl-substituted hydroxamic acid derivatives of the formula Image (I) wherein R represents hydrogen, lower alkyl, halogen or lower alkoxy; R1 and R2 indepen- dently represent hydrogen, lower alkyl or aryl; Y represents a direct bond, lower alkylene, lower alkenylene, lower alkadienylene, (thio, sulfinyl or sulfonyl)-lower alkylene or oxy- lower alkylene; Z represents Image (a) wherein R3 represents hydrogen or acyl; R4 represents lower alkyl, C3-C7-cycloalkyl, aryl or aryl-lower alkyl; or Z represents Image l (b) wherein R3 represents hydrogen or acyl; R5 represents lower alkyl, C3-C7-cycloalkyl, aryl, aryl-lower alkyl, amino or N-(mono- or di-lower alkyl)-amino; R6 and R7 represent hydrogen or lower alkyl; and pharmaceutically acceptable salts thereof provided that R3 represents hydrogen; which are useful as selective lipoxygenase inhibitors, methods for preparation thereof, pharmaceutical compositions comprising said compounds, and a method of inhibiting lipoxygenase and of treating diseases in mammals which are respon- sive to lipoxygenase inhibition using said compounds and pharmaceutical compositions comprising said compounds of the invention.

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