Certain substituted amides, method of making, and method of...

Details Certain substituted amides, method of making, and method of... Certain substituted amides, method of making, and method of...

C - Chemistry, Metallurgy

07

D

C07D 241/08 (2006.01) A61K 31/497 (2006.01) A61P 35/00 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2700443

Compounds of Formula I that inhibit Btk are described herein. Pharmaceutical compositions comprising at least one compound of Formula I, together with at least one pharmaceutically acceptable vehicle chosen from carriers, adjuvants, and excipients, are described. Methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and/ or B-cell activity are described. Methods for determining the presence of Btk in a sample are described.

L'invention concerne des composés de formule I qui inhibent Btk. Elle concerne des compositions pharmaceutiques comprenant au moins un composé de formule I, combiné à au moins un véhicule pharmaceutiquement acceptable choisi parmi des supports, des adjuvants et des excipients. Elle concerne également des procédés de traitement de patients souffrant de certaines maladies qui répondent à une inhibition de l'activité de Btk et/ou de l'activité des cellules B. Elle concerne des procédés pour déterminer la présence de Btk dans un échantillon.

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