Certain substituted benzylamine derivatives; a new class of...

Details Certain substituted benzylamine derivatives; a new class of... Certain substituted benzylamine derivatives; a new class of...

C - Chemistry, Metallurgy

07

D

C07D 295/135 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 213/75 (2006.01) C07D 215/38 (2006.01) C07D 233/36 (2006.01) C07D 233/38 (2006.01) C07D 295/155 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2261031

This invention encompasses compounds of formula (I) and the pharmaceutically acceptable salts thereof wherein X1, X2, X3 represent organic or inorganic substituents, n is 1, 2, or 3, m is 2, 3, or 4, R1-R4 are hydrogen or organic substituents, and B is nitrogen, carbon, sulfur or oxygen, useful in the diagnosis and treatment of feeding disorders such as obesity and bulimia and cardiovascular diseases such as essential hypertension and congestive heart failure due to the binding of these compounds to mammalian Neuropeptide Y1 receptors.

La présente invention se rapporte à des composés représentés par la formule (I) et à des sels pharmaceutiquement acceptables de ces composés. Dans la formule (I), X¿1?, X¿2? et X¿3? représentent des substituants organiques ou inorganiques, n est un entier compris entre 1 et 3, m est égal à 2, 3 ou 4, R¿1?-R¿4? sont hydrogène ou des substituants organiques, B est azote, carbone, soufre ou oxygène. Lesdits composés s'avèrent utiles s'agissant du diagnostic et du traitement des troubles de l'alimentation, tels que l'obésité et la boulimie, et des maladies cardio-vasculaires, telles que l'hypertension artérielle essentielle et l'insuffisance cardiaque globale, en raison de la fixation de ces composés aux récepteurs de neuropeptides Y1 d'origine mammalienne.

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