C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/20 (2006.01) A61K 31/4015 (2006.01) A61K 31/4166 (2006.01) A61K 31/421 (2006.01) C07D 207/26 (2006.01) C07D 233/32 (2006.01) C07D 263/22 (2006.01) C07D 263/24 (2006.01) C07D 285/10 (2006.01) C07D 401/04 (2006.01) C07D 413/04 (2006.01) C07D 413/10 (2006.01) C07D 417/04 (2006.01) C07D 417/10 (2006.01)
Patent
CA 2570717
Compounds having the structures of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis: In the compounds of Formula (I), B or R2 is a phenyl group which has an ortho aryl, heterocyclic, benzoheterocyclic or benzocycloalkyl substituent, and one other position on the 5-membered ring has an aromatic, heterocyclic, cycloalkyl, benzoheterocyclic or benzocycloalkyl substituent connected directly to the ring or attached to the ring through a - CH2-.
Des composés ayant les structures de formule I, y compris des sels acceptables du point de vue pharmaceutique des composés, sont des inhibiteurs de la CETP et sont utiles pour élever le cholestérol HDL, réduire le cholestérol LDL et pour traiter ou prévenir l'athérosclérose : dans les composés de formule I, B ou R2 est un groupe phényle qui a un substituant aryle, hétérocyclique, benzohétérocyclique ou benzocycloalkyle en ortho et une autre position sur le cycle à cinq éléments a un substituant aromatique, hétérocyclique, cycloalkyle, benzohétérocyclique ou benzocycloalkyle lié directement au cycle ou attaché au cycle via un groupe -CH2-.
Ali Amjad
Chen Yi-Heng
Deng Qiaolin
Dowst Adrian A.
Hunt Julianne A.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
LandOfFree
Cetp inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cetp inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cetp inhibitors will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1425825