C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/02 (2006.01) A61K 31/421 (2006.01) A61K 31/4439 (2006.01) C07D 263/16 (2006.01)
Patent
CA 2635083
Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), B is a cyclic group other than phenyl, and B has a cyclic substituent at a position that is ortho to the position at which B is connected to the remainder of the structure of Formula (I). The 5-membered ring of Formula (I) has a second cyclic substituent in addition to B.
Des composés à structure de formule (I), y compris des sels pharmaceutiquement acceptables de ces composés, sont des inhibiteurs de CETP qui s'avèrent utiles pour augmenter le cholestérol HDL, réduire le cholestérol LDL, traiter ou prévenir l'athérosclérose. Dans les composés de formule (I), B est un groupe cyclique autre que phényle et B a un substituant cyclique en position ortho relativement à la position où B est lié au résidu de la structure de formule (I). Le noyau à 5 membres de formule (I) a un deuxième substituant cyclique en plus de B.
Ali Amjad
Chen Yi-Heng
Li Hong
Lu Zhijian
Sinclair Peter J.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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