Cetp inhibitors derived from benzoxazole arylamides

Details Cetp inhibitors derived from benzoxazole arylamides Cetp inhibitors derived from benzoxazole arylamides

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/423 (2006.01) A61K 31/4439 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) C07D 263/57 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2689525

Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are potent CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In formula I, A-B is an arylamide moiety.

L'invention concerne des composés présentant une structure de formule I, ainsi que des sels acceptables sur le plan pharmaceutique desdits composés, qui sont de puissants inhibiteurs de CETP, qui sont utiles pour augmenter le HDL cholestérol, réduire le LDL cholestérol, et qui permettent de traiter ou de prévenir l'athérosclérose. Dans la formule I, A-B est un fragment arylamide.

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