Cetp inhibitors derived from benzoxazole arylamides

Details Cetp inhibitors derived from benzoxazole arylamides Cetp inhibitors derived from benzoxazole arylamides

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/423 (2006.01) A61K 31/454 (2006.01) A61K 31/506 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) C07D 263/57 (2006.01) C07D 413/12 (2006.01) C07D 471/10 (2006.01)

Patent

CA 2689575

Compounds having the structure of Formula I1 including pharmaceutically acceptable salts of the compounds, are potent CETP (cholesterol ester transfer protein) inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis Atherosclerosis and its clinical consequences, coronary heart disease (CHD), stroke and penpheral vascular disease, represent a truly enormous burden to the health care systems ofthe industrialized world In formula I, A-B is an arylamide moiety

L'invention concerne des composés présentant une structure de formule I, ainsi que des sels acceptables sur le plan pharmaceutique desdits composés, qui sont de puissants inhibiteurs de CETP (protéine de transfert des esters de cholestérol), qui sont utiles pour augmenter le HDL cholestérol, réduire le LDL cholestérol, et qui permettent de traiter ou de prévenir l'athérosclérose. L'athérosclérose et ses conséquences cliniques, les coronaropathies (CHD), les AVC et maladies vasculaires périphériques, représentent un véritable fardeau pour les systèmes de soins de santé dans le monde industrialisé. Dans la formule I, A-B est un fragment arylamide.

Affiliated with

Also associated with

Rating

Cetp inhibitors derived from benzoxazole arylamides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cetp inhibitors derived from benzoxazole arylamides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cetp inhibitors derived from benzoxazole arylamides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1813003