Cftr modifier genes and expressed polypeptides useful in...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) A61K 31/00 (2006.01) A61K 31/352 (2006.01) A61K 31/522 (2006.01) A61K 38/17 (2006.01) A61P 37/00 (2006.01) C07K 14/47 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2488012

The discovery that CFTR modifier genes, in particular the Kir4.2 gene, the expressed polypeptide(s), as well as genetic and polypeptide regulators thereof, can be used to treat cystic fibrosis (CF), or at least the conditions that cause CF. Methods and products for detecting and/or identifying CFTR modifier genes, their respective expressed polypeptides, the genetic regulators of such CFTR modifier genes, and the regulators of their respective expressed polypeptides are disclosed. Also disclosed are compositions and methods using these CFTR modifier genes, their respective expressed polypeptides, genetic regulators of these CFTR modifier genes, and/or CFTR modifier polypeptide regulators for the purpose of treating CF, or at least the conditions that cause CF, are disclosed.

On a découvert que des gènes modificateurs CFTR, en particulier le gène Kir4.2, qu'un ou des polypeptides exprimés, ainsi que des régulateurs génétiques et polypeptidiques de ces derniers, peuvent être utilisés pour traiter la mucoviscidose (CF) ou au moins, les états (CF) que cette maladie entraîne. La présente invention concerne des techniques et des produits permettant de détecter et/ou d'identifier des gènes modificateurs CFTR, leurs polypeptides exprimés respectifs, les régulateurs génétiques de ces gènes modificateurs CFTR et les régulateurs de leurs polypeptides exprimés respectifs. Cette invention concerne aussi des compositions et des techniques qui utilisent ces gènes modificateurs CFTR, leurs polypeptides exprimés respectifs, des régulateurs génétiques de ces gènes modificateurs CFTR et/ou des régulateurs de polypeptide modificateur CFTR dans le but de traiter la mucoviscidose (CF) ou au moins, les états que cette maladie (CF) entraîne.

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