Cgmp pde 5 inhibitors for inhalation in the treatment of...

A - Human Necessities – 61 – K

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A61K 31/519 (2006.01) A61K 9/72 (2006.01) A61K 31/517 (2006.01) A61P 15/00 (2006.01) A61P 15/10 (2006.01) A61K 31/00 (2006.01)

Patent

CA 2355368

Treatment of sexual dysfunction by inhalation of a cGMP PDE 5 inhibitor, especially 5-[2-ethoxy- 5-(4-methylpiperazinylsulfonyl )phenyl] -1-methyl- 3-n- propyl-1, 6-dihydro-7H- pyrazolo[4, 3-d]pyrimidin -7-one, 4-phenylmethylamino - 6-chloro-2- (1-imidazolyl) quinazoline, 4-phenylmethylamino -6-chloro-2-( 3- pyridyl) quinazoline, 1,3-dimethyl- 6-(2-propoxy- 5- methanesulfonylamidophenyl) -1,5-dihydropyrazolo[ 3,4-d]pyrimidin -4-one or 1- cyclopentyl-3- ethyl-6-( 3-ethoxy-4- pyridyl) -pyrazolo[ 3,4-d]pyrimidin -4- one.

L'invention concerne le traitement de troubles sexuels par l'inhalation d'inhibiteurs de l'acide guanosine-3'-5'-monophosphate cyclique phosphodiestérases 5, en particulier de 5-[2-éthoxy-5-(4-méthylpipérazinylsulfonyl)phényl]-1-méthyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, 4-phénylméthylamino-6-chloro-2-(1-imidazolyl)quinazoline, 4-phénylméthylamino-6-chloro-2-(3-pyridyl)quinazoline, 1,3-diméthyl-6-(2-propoxy-5-méthanesulfonylamidophényl)-1,5-dihydropyrazolo[3,4-d]pyrimidin-4-one or 1-cyclopentyl-3-éthyl-6-(3-éthoxy-4-pyridyl)-pyrazolo[3,4-d]pyrimidin-4-one.

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