C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2600909
The invention relates to CGRP antagonists of general formula (I) in which: R1, R2, R3, R4 and X are defined as in Claim 1, to their tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and salts as well as the hydrates of the salts, in particular, their physiologically compatible salts with inorganic or organic acids and bases, and those compounds of general formula (I) in which one or more hydrogen atoms are replaced by deuterium. The invention also relates to medicaments containing these compounds, the use thereof, and to methods for producing them.
L'invention concerne des antagonistes CGRP de formule (I), dans laquelle R1, R2, R3, R4 et X sont spécifiés dans la description, leurs tautomères, leurs isomères, leurs diastéréomères, leurs énantiomères, leurs hydrates, leurs mélanges et leurs sels ainsi que les hydrates de sels, en particulier leur sels physiologiquement acceptables comprenant des acides ou des bases organiques ou inorganiques, ainsi que les composés de formule (I), dans lesquels un ou plusieurs atomes d'oxygène sont remplacés par du deutérium. L'invention concerne également les médicaments contenant les composés, leur utilisation ainsi qu'un procédé permettant de les produire.
Arndt Kirsten
Doods Henri
Lustenberger Philipp
Mueller Stephan Georg
Paleari Fabio
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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