Cgrp receptor antagonists

Details Cgrp receptor antagonists Cgrp receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) A61P 25/06 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2583534

Compounds of Formula (I) and Formula (II) (where variables R1, R2, R4, A, B, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

L'invention concerne des composés représentés par les formules I et II (dans lesquelles les variables R1, R2, R4, A, B, W, X, Y et Z sont telles que définies dans la demande), qui sont utiles comme antagonistes des récepteurs du CGRP et destinés à traiter ou à prévenir des maladies dans lesquelles le CGRP intervient, telles que la céphalée, la migraine et la céphalée vasculaire de Horton. L'invention concerne aussi des compositions pharmaceutiques comprenant ces composés et l'utilisation des compositions et composés pour prévenir ou traiter des maladies le CGRP intervient.

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