Cgrp receptor antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 519/00 (2006.01) A61K 31/55 (2006.01) A61P 1/08 (2006.01) A61P 25/06 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2583536

Compounds of Formula (I): and Formula (II): (where variables R2, R4, A, B, D, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

La présente invention décrit des composés de Formule (I) : et de Formule (II) : (où les variables R2, R4, A, B, D, W, X, Y et Z sont telles que définies dans la présente invention), qui peuvent être employés en tant qu'antagonistes aux récepteurs de cGRP et entrer dans le traitement prophylactique ou thérapeutique de maladies dans lesquelles cGRP est impliqué, telles que les maux de tête, les migraines et les algies vasculaires de la face. La présente invention a également pour objet des préparations pharmaceutiques comprenant lesdits composés, ainsi que l~utilisation desdits composés et desdites préparations dans le traitement prophylactique ou thérapeutique de maladies dans lesquelles cGRP est impliqué.

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