C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/20 (2006.01) A61K 31/438 (2006.01) A61K 31/4545 (2006.01) A61K 31/499 (2006.01) A61K 31/5377 (2006.01) A61P 25/06 (2006.01) C07D 471/04 (2006.01) C07D 491/107 (2006.01)
Patent
CA 2739021
Compounds of Formula (I): (wherein variables A'1 A2, A3 A4 A5, A6, A7, A8, J, Q, R4, E a, E b, E c, R6, R7, R e, R f, R PG, and Y and Z are as described herein) useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.
La présente invention concerne des composés de formule (I) : (dans laquelle les variables A1, A2, A3 A4 A5, A6, A7, A8, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG et Y et Z sont telles que décrites dans ce document) utiles en tant quantagonistes des récepteurs du CGRP, et utiles dans le traitement et la prévention de maladies dans lesquelles les récepteurs du CGRP sont impliqués, telles quune céphalée, et en particulier la migraine et lalgie vasculaire de la face. Linvention concerne également des compositions pharmaceutiques renfermant ces composés et lutilisation de ces composés et compositions dans la prévention ou le traitement de telles maladies dans lesquelles les récepteurs du CGRP sont impliqués.
Bell Ian M.
Staas Donnette D.
Wood Michael R.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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