C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/55 (2006.01) A61P 25/06 (2006.01) C07D 473/28 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2522220
The present invention is directed to compounds of Formula (I) and Formula (II) (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
La présente invention concerne des composés représentés par la formule générale (I) et par la formule générale (II) (dans lesquelles les variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X et Y sont définies dans la partie descriptive de la présente demande), utilisés comme antagonistes des récepteurs CGRP et destinés au traitement ou à la prévention de pathologies liées au CGRP, telles que la céphalée, la migraine et la céphalée vasculaire de Horton. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et de compositions dans la prévention et le traitement de telles pathologies liées au CGRP.
Burgey Christopher S.
Deng Zhengwu J.
Nguyen Diem N.
Paone Daniel V.
Shaw Anthony W.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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