C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4545 (2006.01) C07D 401/14 (2006.01) C07D 471/02 (2006.01) C07D 471/20 (2006.01)
Patent
CA 2599925
Compounds of Formula (I), (where variables R1, A, B, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
L'invention porte sur des composés de formule (I) (dans laquelle: les variables R1, A, B, W, X, Y et Z sont définies dans la description) antagonistes du récepteur du CGRP s'avérant utiles pour la prévention et le traitement de maladies où le CGRP joue un rôle tels que les maux de tête, la migraine et l'AVF. L'invention porte également sur des préparations pharmaceutiques comprenant ces composés, et sur l'utilisation de ces composés et préparations pour la prévention et le traitement de maladies où le CGRP joue un rôle.
Burgey Christopher S.
Graham Samuel L.
Nguyen Diem N.
Paone Daniel V.
Shaw Anthony W.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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