C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/02 (2006.01) A61K 31/33 (2006.01) A61K 31/4184 (2006.01) A61K 31/435 (2006.01) A61P 25/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 453/02 (2006.01) C07D 471/04 (2006.01) C07D 471/08 (2006.01) C07D 498/18 (2006.01)
Patent
CA 2683581
Compounds of formula I: (I) (wherein variables A, m, n, J, Re, Rf, R4, Ea, Eb, Ec, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
La présente invention concerne des composés représentés par la formule (I) (dans laquelle les variables A, m, n, J, Re, Rf, R4, Ea, Eb, Ec, RPG et Y sont telles que décrites dans le descriptif) qui sont des antagonistes des récepteurs CGRP et qui sont utiles dans le traitement ou la prévention de maladies dans lesquelles le CGRP est impliqué, telles que la migraine et concerne des compositions pharmaceutiques comprenant ces composés ainsi que l'utilisation de ces composés et compositions dans la prévention ou le traitement des maladies dans lesquelles CGRP est impliqué.
Kim June
Mcwherter Melody
Schirripa Kathy
Selnick Harold G.
Wood Michael R.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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