C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 49/813 (2006.01) A61K 31/12 (2006.01) A61P 17/00 (2006.01) A61P 35/00 (2006.01) C07C 49/217 (2006.01) C07C 49/223 (2006.01) C07C 49/233 (2006.01) C07C 49/235 (2006.01) C07C 49/683 (2006.01) C07C 49/697 (2006.01) C07C 49/782 (2006.01) C07C 49/796 (2006.01) C07C 49/84 (2006.01) C07D 207/32 (2006.01) C07D 207/333 (2006.01) C07D 213/50 (2006.01) C07D 307/46 (2006.01)
Patent
CA 2395191
The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.
La présente invention concerne la chalcone, ses dérivés et ses analogues, utiles en tant qu'inhibiteurs de l'angiogenèse. Ces composés, dont la synthèse est peu onéreuse, présentent une activité inhibitrice de l'angiogénèse inopinément bonne. La présente invention concerne également l'utilisation de la chalcone et de ses analogues comme agents antitumoraux/anticancéreux, ainsi que le traitement de plusieurs états pathologiques ou maladies dans lesquels l'angiogenèse est un facteur, y compris des maladies angiogéniques de la peau telles que le psoriasis, l'acné, la couperose, les verrues, l'eczéma, l'hémangiome, la lymphangiogénèse, ainsi que des maladies inflammatoires chroniques telles que l'arthrite.
Arbiser Jack
Bowen J. Phillip
Ehlers Tedman
Goldsmith David
Robinson Thomas Philip
Cassan Maclean
Emory University
The University Of Georgia Research Foundation Inc.
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