Champ - a cardiac helicase-like factor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/55 (2006.01) A01K 67/027 (2006.01) A61K 38/46 (2006.01) A61K 38/52 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) A61P 9/02 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 9/14 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01) C12Q 1/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2438597

The present invention relates to a new polypeptide and the gene encoding therefore, said gene being regulated in cardiac tissue by the transcription factor MEF2C. This polypeptide, CHAMP (cardiac helicase activated by MEF2 protein), bears striking resemblance to a number of other helicase proteins and appears to play a role in RNA processing and transcriptional control in heart muscle. For example, CHAMP has been demonstrated to inhibit both hypertrophy of primary cardiomyocytes and proliferation of non-cardiac cells. Also disclosed are methods of using the gene and protein in drug screening and therapy, including, for example, use of the gene in gene therapy to treat cardiovascular disease.

La présente invention concerne un nouveau polypeptide et le gène codant pour celui-ci, ce gène étant régulé dans le tissu cardiaque par le facteur de transcription MEF2C. Ce polypeptide, appelé CHAMP (hélicase cardiaque activée par la protéine MEF2), présente une ressemblance frappante avec une pluralité d'autres protéines hélicases et semble jouer un rôle dans la maturation de l'ARN et dans la régulation transcriptionnelle dans le muscle cardiaque. Par exemple, on a démontré que CHAMP inhibe l'hypertrophie des cardiomyocytes primaires ainsi que la prolifération de cellules non cardiaques. L'invention concerne également des méthodes d'utilisation de ce gène et de cette protéine dans le criblage de médicaments et dans la thérapie. Elle se rapporte notamment à l'utilisation de ce gène dans la thérapie génique en vue traiter une maladie cardiovasculaire.

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