Channel forming toxins as antiviral agents

Details Channel forming toxins as antiviral agents Channel forming toxins as antiviral agents

C - Chemistry, Metallurgy

12

N

C12N 7/06 (2006.01) A61K 38/16 (2006.01) A61K 39/12 (2006.01) A61K 39/21 (2006.01) A61L 2/00 (2006.01) A61P 31/18 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2366794

The infectivity of a population of enveloped viruses which comprise a glycosylphosphatidylinositol-anchored protein in their membrane can be reduced by employing certain toxins such as aerolysin, alpha toxin of Clostridium septicum, or enterolobin. Toxins which bind to glycosylphosphatidylinositol- anchored proteins inactivate such viruses. The toxins can be used to produce attenuated viral vaccines, to purge blood products, cells, or tissues of such viruses, and to detect viruses in samples.

Pour diminuer l'infectivité d'une population de virus enveloppés qui comprennent une protéine ancrée à glycosylphosphatidylinositol dans leur membrane, on utilise certaines toxines telles que l'aérolysine, la toxine alpha de Clostridium septicum ou l'entérolobine. Les toxines qui se lient à des protéines ancrées à glycosylphosphatidylinositol inactivent ces virus. Ces toxines peuvent servir à produire des vaccins viraux atténués, à purger des produits sanguins, des cellules ou des tissus desdits virus et à détecter lesdits virus dans des échantillons.

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