G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/50 (2006.01) C12Q 1/02 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2290038
The invention relates to a method for determining whether a fragment of a molecular chaperone is active in vivo, comprising the steps of: a) providing a cell with a deficient molecular chaperone activity; b) administering the molecular chaperone fragment to the cell; and c) determining whether the molecular chaperone fragment complements the deficient endogenous molecular chaperone activity, as well as to methods for providing molecular chaperone activities in vivo.
La présente invention porte sur un procédé permettant de déterminer si un fragment d'une molécule chaperonne est actif in vivo. Ce procédé consiste à: a) produire une cellule ayant une activité de molécule chaperonne déficiente; b) administrer le fragment de la molécule chaperonne à la cellule; et c) déterminer si le fragment de la molécule chaperonne complète l'activité déficiente de la molécule chaperonne endogène. L'invention porte également sur des procédés de production des activités des molécules chaperonnes in vivo.
Chatellier Jean
Fersht Alan
Hill Fergal
Medical Research Council
Smart & Biggar
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