Chaperonin 10 immunosuppression

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/17 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2505141

The invention is directed to the use of cpn10 in transplantation and particularly to treatment and/or prevention of graft versus host disease. The invention provides a method of administration of cpn10 to a donor and/or recipient animal or cells, tissues or organs derived from the donor, although in a particularly advantageous form treatment of both the donor and recipient animal. The method may further include the administration to the donor and/or recipient animal at least one other immunosuppressive agent to prevent or alleviate graft versus host disease.

La présente invention concerne l'utilisation de cpn 10 dans une transplantation et en particulier pour le traitement et/ou la prévention d'une maladie du greffon contre l'hôte. Cette invention concerne une technique d'administration de cpn 10 à un animal donneur et/ou receveur ou à des cellules, des tissus ou des organes issus du donneur, bien qu'un traitement de forme particulièrement intéressante concerne une administration à l'animal donneur et à l'animal receveur. Cette technique peut aussi consister à administrer à l'animal donneur et/ou receveur au moins un autre agent immunosuppresseur destiné à prévenir ou atténuer une maladie du greffon contre l'hôte.

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