Chaperonin 10-induced immunomodulation

A - Human Necessities – 61 – K

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A61K 38/16 (2006.01)

Patent

CA 2614480

The present invention relates to methods for modulating Toll-like receptor signalling in a subject, or in at least one cell, tissue or organ thereof, methods for treating or preventing a disease or condition in a subject, methods for modulating the production and/or secretion of one or more immunomodulators in a subject, or at least one cell, tissue or organ thereof, wherein said methods involve the administration of chaperonin 10, and wherein the chaperonin 10 associates with a Toll-like receptor in an activation cluster. Also contemplated are associated compositions and uses thereof.

La présente invention concerne des méthodes de modulation de la signalisation de récepteurs de type chez un sujet, ou au moins dans une cellule, un tissu ou un organe de ce sujet, ainsi que des méthodes de traitement ou de prévention d'une maladie ou d'un état chez un sujet, des méthodes de modulation de la production et/ou de la sécrétion d'un ou de plusieurs immunomodulateurs chez un sujet, ou au moins dans une cellule, un tissu ou un organe de ce sujet. Ces méthodes consistent dans l'administration de chaperonine 10, laquelle s'associe avec un récepteur de type Toll en un amas d'activation. Sont également décrites des compositions connexes et leurs utilisations.

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