C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2303790
The present invention provides a method for analysing a population of nucleic acid fragments each labelled with a mass label, which method comprises: i) ionising the population; ii) sorting the ionised population in a mass spectrometer according to mass into sub-populations each containing at least one labelled fragment; iii) cleaving each sub-population to release the mass label associated with each labelled fragment; iv) determining the mass of each released mass label by mass spectroscopy; and v) assigning each mass label to its associated fragment.
La présente invention concerne un procédé permettant d'analyser une population de fragments d'acide nucléiques tous marqués par un marqueur de masse. Ce procédé consiste: i.) à ioniser la population; ii.) à trier en sous-populations, en fonction de la masse, la population ionisée dans un spectromètre de masse, chaque sous-population contenant au moins un fragment marqué; iii.) à cliver chaque population de façon à détacher le marqueur de masse associé à chaque fragment marqué; iv.) à évaluer par spectroscopie de masse la masse de chaque marqueur de masse détaché; et v.) à affecter chaque marqueur de masse au fragment qui lui est associé.
Schmidt Gunter
Thompson Andrew Hugin
Brax Group Limited
Ridout & Maybee Llp
Xzillion Gmbh & Co. Kg
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