C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 195/1.2,
C12N 15/12 (2006.01) C07K 14/535 (2006.01) C12N 1/20 (2006.01) C12N 9/52 (2006.01) C12N 9/90 (2006.01) C12N 15/76 (2006.01) C12P 21/04 (2006.01)
Patent
CA 1295566
ABSTRACT OF THE DISCLOSURE A DNA signal sequence initially isolated from Streptomyces griseus encodes a signal peptide which directs the secretion, via a fused intermediate, of a protein from the cell within which the DNA signal sequence is expressed. The signal sequence is derived from genes encoding protease A and protease B of S. griseus. The DNA signal sequence encodes a thirty-eight amino acid signal peptide. A DNA construct, including the DNA signal sequence and a gene sequence encoding a protein, when transformed into a living cell by a suitable vector, results in the signal peptide correctly directing the secretion of a mature protein of desired structure, particularly from prokaryotic genera selected for their ability to display enzymatic activity of a type typified by, but not exlusive to, that of protein disulphide oxidoreductase, EC 5.3.4.1, more particularly in the genera Streptomyces, and most particularly in Streptomyces lividans 66. 8753b/38
542678
Davey Cheryl
Garvin Robert T.
Henderson Graham
Krygsman Phyllis
Liu Ci Jun
Blake Cassels & Graydon Llp
Cangene Corporation
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