Characterization and use of an isolated uridine...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/54 (2006.01) A61K 31/70 (2006.01) A61K 38/45 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 9/10 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2255712

A uridine diphospho-glucuronosyltransferase (UGTB217) is provided. Methods of producing the enzyme and using the enzyme to identify potential compounds which inhibit or alter the activity of the enzyme are described. In addition, methods of using antibodies to localize the protein, or using the gene sequence or portions thereof for probes or using the gene sequence to produce expression-disrupting sense or antisense DNA fragments thereof, or antisense RNA, are provided.

Cette invention se rapporte à une uridine diphospho-glucuronosyltransférase (UGTB217). L'invention concerne des procédés de production de cette enzyme et de son utilisation relative à l'identification de composés susceptibles d'inhiber ou de modifier l'activité de ladite enzyme. L'invention se rapporte également à des procédés d'utilisation d'anticorps pour localiser cette protéine, ou d'utilisation de la séquence d'un gène ou de parties de cette séquence pour la fabrication de sondes, ou d'utilisation de la séquence d'un gène pour produire des fragments d'ADN antisens ou signifiants, à effet perturbateur d'expression, de cette séquence ou de l'ARN antisens.

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