C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2142724
2142724 9407502 PCTABS00032 In accordance with the present invention, there is provided an isolated peptide having the characteristics of human trithorax protein (as well as DNA encoding same, antisense DNA derived therefrom and antagonists therefor). The invention peptide is characterized by having a DNA binding domain comprising multiple zinc fingers and at least 40 % amino acid identity with respect to the DNA binding domain of Drosophila trithorax protein and at least 70 % conserved sequence with respect to the DNA binding domain of Drosophila trithorax protein, and wherein said peptide is encoded by a gene located at chromosome 11 of the human genome at q23. Also provided are methods for the treatment of subject(s) suffering from immunodeficiency, developmental abnormality, inherited disease, or cancer by administering to said subject a therapeutically effective amount of one of the above-described agents (i.e., peptide, antagonist therefor, DNA encoding said peptide or antisense DNA derived therefrom). Also provided is a method for the diagnosis, in a subject, of immunodeficiency, developmental abnormality, inherited disease, or cancer associated with disruption of chromosome 11 at q23.
Djabali Malek
Evans Glen A.
Parry Pauline
Selleri Licia
Gowling Lafleur Henderson Llp
The Salk Institute For Biological Studies
LandOfFree
Characterization of a chromosome 11q23 translocation... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Characterization of a chromosome 11q23 translocation..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Characterization of a chromosome 11q23 translocation... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1723961