Characterization of a mekk binding site and uses thereof

Details Characterization of a mekk binding site and uses thereof Characterization of a mekk binding site and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/08 (2006.01) A61K 38/17 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C12Q 1/48 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2583999

The present invention provides binding motifs, binding sites, peptides, and 14-3-3 / MEKK complexes. Also provided are agents reactive with same, pharmaceutical compositions, molecules, and kits comprising same, and methods of producing same. The present invention further provides isolated nucleic acids and constructs comprising same, host cells comprising the constructs, and transgenic non-human animals. Additionally, the present invention provides methods of: (a) facilitating or inhibiting 14-3-3 / MEKK interaction, (b) regulating MEKK activity, (c) identifying agents that interact with MEKK or 14- 3-3, (d) detecting and monitoring the development of MEKK-mediated conditions, and (e) treating and/or preventing MEKK-mediated conditions.

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