Characterization of platelet aggregation disorders

Details Characterization of platelet aggregation disorders Characterization of platelet aggregation disorders

G - Physics

01

N

G01N 33/577 (2006.01) C07K 16/28 (2006.01) G01N 33/567 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2096230

Methods are described for characterizing platelet aggregation defects. The defects are characterized as activation, ligand binding, or post-occupancy defects. In one embodiment of the invention a Cam variant of Glanzmann's thrombastenia is charac- terized as having a ligand binding defect. In another embodiment, a patient with myelofibrosis is identified as having an activa- tion defect. Rapid analysis are afforded using fluorescence-activated flow cytometry. Also, diagnostic kits are described which comprise antibodies suitable for characterizing the above defects.

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