Charged phospholipid compositions and methods for their use

Details Charged phospholipid compositions and methods for their use Charged phospholipid compositions and methods for their use

A - Human Necessities

61

K

A61K 31/683 (2006.01) A23J 7/00 (2006.01) A61K 31/66 (2006.01) A61K 31/663 (2006.01) A61K 31/685 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2455170

The invention provides a pharmaceutical composition comprising a synthetic or naturally occurring charged phospholipid, which is formulated into a dosage form for administration to a subject or which is administered as a food additive. Negatively charged phospholipid composition increase the net negative charge on intravascular lipoproteins, enhance the clearance of cholesterol and regulate the function of lipolytic enzymes, retard prothrombin formation and aid in the clearance of virus and bacterial particles. Negatively charged lipid compositions can therefore be administered to humans and animals for the treatment of hyperlipidemia and blood coagulation disorders and to reduce the levels of virus, bacteria, and endotoxins in the blood stream. Positively charged lipid compositions can be administered to delay lipoprotein clearance from the plasma compartment and give longer duration of activity for drugs which are associated with lipoproteins.

Composition pharmaceutique qui comporte un phospholipide chargé synthétique ou naturel, préparée sous une forme galénique destinée à être administrée à un sujet ou qui est administrée en tant qu'additif alimentaire. Des compositions phospholipidiques négativement chargées augmentent la charge négative nette sur les lipoprotéines intravasculaires, favorisent l'élimination du cholestérol et régulent la fonction des enzymes lipolytiques, retardent la formation de la prothrombine et contribuent à l'élimination des particules virales et bactériennes. Des compositions lipidiques négativement chargées peuvent par conséquent être administrées aux humains et aux animaux pour le traitement de l'hyperlipidémie et des troubles de la coagulation sanguine et pour réduire les taux de virus, de bactéries et d'endotoxines dans le flux sanguin. Des compositions lipidiques chargées positivement peuvent être administrées pour retarder l'élimination des lipoprotéines plasmatiques et prolonger l'action de médicaments associés à ces lipoprotéines.

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