Chds as modifiers of the p53 pathway and methods of use

Details Chds as modifiers of the p53 pathway and methods of use Chds as modifiers of the p53 pathway and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) A01N 43/04 (2006.01) A01N 61/00 (2006.01) A61K 31/00 (2006.01) A61K 31/07 (2006.01) A61K 35/14 (2006.01) A61K 38/00 (2006.01) C07H 1/00 (2006.01) C07H 5/04 (2006.01) C07H 5/06 (2006.01) C07H 19/00 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C07K 2/00 (2006.01) C07K 4/00 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01) C08B 37/00 (2006.01) C12Q 1/42 (2006.01) C12Q 1/48 (2006.01) C12Q 1/527 (2006.01

Patent

CA 2449482

Human CHD genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of CHD are provided.

L'invention concerne les gènes CHD humains identifiés comme étant des modulateurs du mécanisme d'action de p53, et qui sont de ce fait des cibles thérapeutiques pour les troubles associés à une fonction p53 défectueuse. L'invention concerne également des procédés permettant d'identifier des modulateurs de p53, comprenant un criblage visant à rechercher des agents qui modulent l'activité de CHD.

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