Chelating immunostimulating complexes

Details Chelating immunostimulating complexes Chelating immunostimulating complexes

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2279935

An immunostimulating complex matrix comprising a saponin preparation, a sterol and a phospholipid, the matrix further comprising a metal-chelating moeity capable of binding a protein or polypeptide having at least one chelating amino acid sequence in the presence of metal ions. An immunogenic immunostimulating complex which comprises this matrix and an immunogenic protein or polypeptide having at least one chelating amino acid sequence, the protein or polypeptide being bound to the matrix in the presence of metal ions.

Matrice complexe immunostimulant comprenant une préparation de saponine, un stérol et un phospholipide. La matrice comprend en outre un fragment chélateur métallifère capable de se lier à une protéine ou à un polypeptide présentant au moins une séquence d'acides aminés chélateurs en présence d'ions métalliques. L'invention concerne aussi un complexe immunostimulant immunogène qui comprend cette matrice et une protéine ou un polypeptide immunogène présentant au moins une séquence d'acides aminés chélateurs, la protéine ou le polypeptide étant lié à la matrice en présence d'ions métalliques.

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