Chelator compositions comprising oxime compounds

Details Chelator compositions comprising oxime compounds Chelator compositions comprising oxime compounds

C - Chemistry, Metallurgy

07

D

C07D 307/52 (2006.01) A61K 31/15 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) C07C 251/38 (2006.01) C07C 251/40 (2006.01) C07C 325/02 (2006.01) C07D 333/22 (2006.01) A61K 7/42 (1995.01)

Patent

CA 2079485

The present invention involves photoprotective compositions which are useful for topical application to prevent damage to skin caused by acute or chronic exposure to ultraviolet light comprising chelating agents having formula (I) wherein -R1 and -R2 are independently selected from the group consisting of alkyl, aryl, and heteroaryl, or R1 and R2 may be covalently bonded together to form a cyclic alkyl; -M is selected from the group consisting of =O, =S, -SR4 and -OR4 (when -M is -OR4 or -SR4, there is a hydrogen bonded to the carbon to which -M is bonded); -R4 is selected from the group consisting of hydrogen, alkyl, aryl and heteroaryl; -R3 is selected from the group consisting of hydrogen, alkyl, aryl and heteroaryl; -R6 is selected from the group consisting of hydrogen, alkyl, aryl and heteroaryl; an i is selected from the group consisting of one and zero. Methods for using such compositions to prevent damage to skin caused by acute or chronic exposure to ultraviolet light are also involved.

Compositions photoprotectrices utiles pour l'application topique en vue de prévenir des lésions de la peau causées par une expositio aiguë ou chronique à la lumière ultraviolette, comprenant des agents chélateurs de la formule (I) dans laquelle -R1 et -R2 sont indépendamment choisis dans le groupe se composant d'alkyle, d'aryle, et d'hétéroaryle, ou R1 et R2 peuvent être liés par covalence pour former un alkyle cyclique; -M est choisi dans le groupe comprenant =O, =S, -SR4 et -OR4 (quand -M est -OR4 ou -SR4, il ya un hydrogène lié au carbone auquel -M est lié); -R4 est choisi dans le groupe se composant d'hydrogène, d'alkyle, d'aryle et d'hétéroaryle; -R3 est choisi dans le groupe se composant d'hydrogène, d'alkyle, d'aryle et d'hétéroaryle; R6 est choisi dans le groupe se composant d'hydrogène, d'alkyle, d'aryle et d'hétéroaryle; et i est choisi dans le groupe se composant de un et de zéro. On décrit aussi des procédés d'utilisation de telles compositions en vue de prévenir des lésions de la peau causées par une exposition aiguë ou chronique à la lumière ultraviolette.

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