Chelator incorporated arg-gly-asp (rgd) mimetic synthetic...

Details Chelator incorporated arg-gly-asp (rgd) mimetic synthetic... Chelator incorporated arg-gly-asp (rgd) mimetic synthetic...

C - Chemistry, Metallurgy

07

K

C07K 5/068 (2006.01) A61K 51/00 (2006.01) A61K 51/04 (2006.01) A61K 51/08 (2006.01) C07K 5/023 (2006.01) C07K 5/09 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2341672

The present invention describes novel compounds of formula (I) wherein R1, R2, R3, R4, and n are as defined herein, which act as antagonists of the platelet glycoprotein IIb/IIIa complex, 99mTc labeled radiopharmaceuticals made therefrom, methods of using the same as imaging agents for the diagnosis of arterial and venous thrombi, and kits comprising the same.

L'invention concerne de nouveaux composés correspondant à la formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿ et n sont définis dans la description, qui fonctionnent comme antagonistes du complexe de glycoprotéine plaquettaire IIb/IIIa, des produits radiopharmaceutiques étiquetés ?99m¿Tc préparés à partir de ces composés, des procédés de leur utilisation comme agents d'imagerie dans le diagnostic de thrombus artériels et veineux ainsi que des kits comprenant ces composants.

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