Chemical cleaning of biological material

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/00 (2006.01) A61L 27/36 (2006.01)

Patent

CA 2288823

The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.

L'invention concerne des tissus collagènes traités de manière à éliminer les composants non collagènes tels que des cellules, des débris cellulaires, ainsi que d'autres composants de matrice extracellulaire, par exemple les protéoglycanes et les glycosaminoglycanes, que l'on trouve habituellement dans les tissus d'origine. Le traitement de ces tissus à l'aide d'agents chélateurs alcalins, d'acides, et de sels permet d'éliminer les composants non collagènes de la matrice tissulaire collagène, tout en régulant son gonflement et sa dissolution, de sorte que la matrice collagène ainsi obtenue conserve son organisation et son intégrité structurelles ainsi que ses propriétés bioremodelables. Le procédé de cette invention permet d'éviter l'utilisation de détergents et d'enzymes qui pourraient nuire à la compatibilité, à la solidité, et à la bioremodelabilité cellulaire de ladite matrice collagène. Cette matrice tissulaire collagène est utilisée, chez un mammifère hôte, à des fins d'implantation, de réparation, ou d'utilisation.

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