A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4439 (2006.01)
Patent
CA 2581180
The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula (1): where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK~) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
L'invention porte sur de nouveaux dérivés d'indole carboxamide, et plus spécifiquement sur des composés de formule (I) dans laquelle: R1, R2, R3, U et V sont définis ci-dessus, et sur leurs sels pharmacocompatibles. Lesdits composés sont des inhibiteurs de l'IKK2, propres à traiter certains troubles associés à une activité non appropriée de l'IKK2 (également connu sous l'appellation d'IKKß), tels que l'arthrite rhumatoïde, l'asthme, et la bronchopneumopathie chronique obstructive. L'invention porte également sur des préparations pharmaceutiques contenant lesdits composés, sur des méthodes d'inhibition de l'activité de l'IKK2, et sur le traitement de troubles lui étant associés à l'aide d'un composé de l'invention eu d'une préparation pharmaceutique le contenant.
Kerns Jeffrey K.
Lin Xichen
Lindenmuth Michael
Nie Hong
Thomas Sonia M.
Glaxo Group Limited
Gowling Lafleur Henderson Llp
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