Chemical compounds

Details Chemical compounds Chemical compounds

C - Chemistry, Metallurgy

07

D

167/218, 260/255

C07D 239/28 (2006.01) A61K 31/505 (2006.01) C07D 239/36 (2006.01) C07D 239/46 (2006.01) C07D 239/54 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2014760

11990 ABSTRACT CHEMICAL COMPOUNDS Compounds of the formula (1) : Image (1) and pharmaceutically acceptable salts thereof are described wherein R1 is C1-6alkyl, C2-6alkenyl, C3-5cycloalkylC1-6alkyl, phenylC1-6alkyl or C1-6alkyl substituted by 1 to 6 fluoro groups; and R2 is C1-6alkyl, phenyl, hydroxy, C1-6alkoxy, halo, -NHCOR3, -NHCONHR4, 5-tetrazolyl, -CO2R5, cyano, -CONR6R7, or -NR8R9 wherein R3 to R7 are independently hydrogen or C1-6alkyl and R8 and R9 are independently hydrogen or C1-6alkyl optionally substituted by hydroxy provided that the carbon atom adjacent to the nitrogen atom is not substituted by hydroxy. Processes for their preparation, pharmaceutical compositions comprising them and their use as medicaments are also described.

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